Mature b cell

This module will help you. Generation of B Cells. The immune system is remarkable for its ability to respond to a great many antigens, including newly synthesized compounds which did not exist until recently. Unusual properties of antibody diversity include the presence of variable and constant regions on the same polypeptide chain and identical V regions used with different C regions.
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B cells immunophenotyping

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B Cell Development

Humoral immunity refers to mechanisms of the adaptive immune defenses that are mediated by antibodies secreted by B lymphocytes, or B cells. This section will focus on B cells and discuss their production and maturation, receptors, and mechanisms of activation. Unlike T cells, however, lymphoblasts destined to become B cells do not leave the bone marrow and travel to the thymus for maturation. Rather, eventual B cells continue to mature in the bone marrow.

Early B cell development and commitment to the B cell lineage occurs in the foetal liver prenatally, before continuing in the bone marrow throughout life. B cells are at the centre of the adaptive humoral immune system and are responsible for mediating the production of antigen-specific immunoglobulin Ig directed against invasive pathogens typically known as antibodies. Several distinct B-cell subsets have been defined that possess distinct functions in both adaptive and innate humoral immune responses. Immunoglobulins consist of two identical heavy and light chains, which are joined by disulphide bonds.
B cells , also known as B lymphocytes , are a type of white blood cell of the small lymphocyte subtype. The "B" from B cells comes from the name of this organ , where it was first discovered by Chang and Glick, [2] and not from bone marrow as commonly believed. B cells, unlike the other two classes of lymphocytes, T cells and natural killer cells , express B cell receptors BCRs on their cell membrane.
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